摘要
Host defence peptides (HDPs) are short cationic molecules produced by the immune systems of most multicellular organisms and play a central role as effector molecules of innate immunity. Host defence peptides have a wide range of biological activities from direct killing of invading pathogens to modulation of immunity and other biological responses of the host. HDPs have important functions in multiple, clinically relevant disease processes and their imbalanced expression is associated with pathology in different organ systems and cell types. Furthermore, HDPs are now evaluated as model molecules for the development of novel natural antibiotics and immunoregulatory compounds. This review provides an overview of HDPs focused on their antimicrobial-immunomodulatory duality.
摘要译文
宿主防御肽（的HDP）是由最多细胞生物体的免疫系统产生的短阳离子分子和发挥作为先天免疫效应分子的中心的作用。宿主防御肽具有广泛的从直接杀伤入侵病原体的免疫力和主机的其他生物反应的调节的生物活性。的HDP具有重要的功能多，临床相关疾病过程和他们的不均衡表达与病理不同的器官系统和细胞类型有关。此外，的HDP现在评价模型分子的新的天然抗生素和免疫调节化合物的开发。这次审查提供的HDP概述专注于自己的抗菌免疫调节双重性。
Lars Steinstraesser; Ursula Kraneburg; Frank Jacobsen; Sammy Al-Benna. Host defense peptides and their antimicrobial-immunomodulatory duality[J]. Immunobiology, 2011,216(3): 322–333